ĶOS718 Selected Chapters of Organic Synthesis

Code ĶOS718
Name Selected Chapters of Organic Synthesis
Status Compulsory/Courses of Limited Choice; Courses of Free Choice
Level and type Post-graduate Studies, Academic
Field of study Chemistry and Chemical Technology
Faculty Department of Chemical Technology of Biologically Active Compounds
Academic staff Māris Turks
Credit points 7.0 (10.5 ECTS)
Parts 1
Annotation This course covers topics on solvent effects on organic reactions, pericyclic reactions and enolate chemistry. Also topics on reactions involving carbocation, carbanion and radical intermediates are covered. Special attention is devoted to chapters dealing with element organic chemistry – organic derivatives of boron, silicon, tin, phosphorous, sulfur and selenium. Introduction to organometallic chemistry is also provided. Each topic contains thorough discussion on reaction mechanisms, regio- and stereoselectivity. Combination of a logic bond disconnection approach based on the novel reactions discussed in this course leads to retrosynthetic analysis. The latter provides the possibility to design the synthesis of virtually every organic compound of medium complexity from simple and commercially available building blocks with the knowledge obtained in this course. .
Goals and objectives
of the course in terms
of competences and skills
Student manages advanced methods of synthesis, has knowledge of synthesis of complicated organic compounds, is able without assistance to evaluate (taking into account drawbacks and advantages), compare and choose the best method from several different methods of synthesis of envisaged compound. Student is able to use his theoretical and practical knowledge, to invent and to realize synthetic scheme of target compound, as well as he is able to study oneself new methods of synthesis. Practical proficiency of work in organic synthesis laboratory is improved as well as new competences are attained.
Learning outcomes
and assessment
Student manages advanced methods of synthesis, has knowledge of synthesis of complicated organic compounds. - Tests and the final exam. 40% of the final assessment is formed from 2 tests during the semester (20% + 20%). 60% of the final assessment is formed from the final exam.
Student is able without assistance to evaluate (taking into account drawbacks and advantages), compare and choose the best method from several different methods of synthesis of envisaged compound. - Tests and the final exam. 40% of the final assessment is formed from 2 tests during the semester (20% + 20%). 60% of the final assessment is formed from the final exam.
Student is able to use his theoretical and practical knowledge to invent and to realize synthetic scheme of target compound, as well as he is able to study oneself new methods of synthesis. - Tests and the final exam. 40% of the final assessment is formed from 2 tests during the semester (20% + 20%). 60% of the final assessment is formed from the final exam.
Course prerequisites Organic chemistry, electron pushing, mechanisms of bond reorganisation, classical methods of organic synthesis

[Extended course information PDF]